α-Lipoic Acid and Cardiovascular Disease

Consequences of the Combined α-tocopherol, Ascorbic Acid and α-lipoic Acid on the Glutathione, Cholesterol and Fatty Acid Composition in Muscle and Liver of Diabetic Rats

α−Lipoic Acid: Biological Effects and Clinical Implications

α−Lipoic acid is unique in its ability to act as an antioxidant in fatand watersoluble tissues in both its oxidized and reduced forms. It is readily absorbed from an oral dose. Because of its myriad biological activities, including an ability to chelate metals and to scavenge a wide array of free radicals, α−lipoic acid is considered by several experts to be an ideal antioxidant. Clinical appli...

!-lipoic Acid in Liver Metabolism and Disease

R-!-Lipoic acid is found naturally occurring as a prosthetic group in !-keto acid dehydrogenase complexes of the mitochondria, and as such plays a fundamental role in metabolism. Although this has been known for decades, only recently has free supplemented !-lipoic acid been found to affect cellular metabolic processes in vitro, as it has the ability to alter the redox status of cells and inter...

Enantioselective Pharmacokinetics of α-Lipoic Acid in Rats

α-Lipoic acid (LA) is widely used for nutritional supplements as a racemic mixture, even though the R enantiomer is biologically active. After oral administration of the racemic mixture (R-α-lipoic acid (RLA) and S-α-lipoic acid (SLA) mixed at the ratio of 50:50) to rats, RLA showed higher plasma concentration than SLA, and its area under the plasma concentration-time curve from time zero to th...

Pharmacokinetics of orally administered DL-α-lipoic acid in dogs.

OBJECTIVE To determine the pharmacokinetics of DL-α-lipoic acid in dogs when administered at 3 dosages via 3 methods of delivery. ANIMALS 27 clinically normal Beagles. PROCEDURES In a 3 × 3 factorial Latin square design, 3 dosages (2.5, 12.5, and 25 mg/kg) of DL-α-lipoic acid were administered orally in a capsule form and provided without a meal, in a capsule form and provided with a meal, ...